What is the difference between IPSS and DIPSS?

IPSS (International Prognostic Scoring System) is applied only at diagnosis and assigns 1 point for each of the 5 risk factors. DIPSS can be applied at any time during the disease course and weights hemoglobin < 10 g/dL as 2 points (instead of 1), making it more dynamic and accurate over time.

What are constitutional symptoms in this context?

Constitutional symptoms include unexplained fever (>37.5°C), drenching night sweats, or unintentional weight loss of more than 10% of body weight over the preceding 12 months.

What is the DIPSS score range and risk grouping?

DIPSS total score ranges from 0 to 6. Score 0 = Low risk (median survival not reached); 1–2 = Intermediate-1 (median ~14 years); 3–4 = Intermediate-2 (median ~4 years); 5–6 = High risk (median ~18 months).

Does DIPSS apply to secondary myelofibrosis?

Yes. DIPSS is validated for primary myelofibrosis (PMF) and also used in secondary myelofibrosis (post-PV MF and post-ET MF), though some guidelines recommend also considering DIPSS-Plus for additional cytogenetic and transfusion-dependency factors.

Can DIPSS be recalculated at follow-up visits?

Yes. Unlike IPSS, DIPSS is specifically designed for repeated application at any time point, making it useful for monitoring disease progression and adjusting treatment strategy.

DIPSS Myelofibrosis Score

Enter five clinical parameters to calculate the DIPSS score and estimate overall survival risk group in myelofibrosis.

Patient Parameters

Enter current clinical values to calculate the DIPSS score.

Age (years)

Score +1 if age > 65

Hemoglobin (g/dL)

Score +2 if < 10 g/dL

WBC count (×10⁹/L)

Score +1 if > 25 ×10⁹/L

Circulating blasts (%)

Score +1 if ≥ 1%

Constitutional symptoms

Fever, night sweats, or weight loss > 10% in past year

Yes (+1) No

Result

Enter patient values and press Calculate.

0 / 6 pts

Risk Group

Factor	Value	Points

DIPSS Risk Scale

Low Score 0 Median OS: not reached

Intermediate-1 Score 1–2 Median OS: ~14 years

Intermediate-2 Score 3–4 Median OS: ~4 years

High Score 5–6 Median OS: ~18 months

For clinical use only. DIPSS is based on Passamonti et al., Blood 2010. Always combine with full clinical assessment.

Summary

The Dynamic International Prognostic Scoring System (DIPSS) is a validated clinical scoring tool used to estimate overall survival in patients with primary or secondary myelofibrosis. It evaluates five independent risk factors: age, hemoglobin level, white blood cell count, circulating blast percentage, and presence of constitutional symptoms. DIPSS improves on the original IPSS by incorporating hemoglobin as a weighted factor (2 points instead of 1), providing more precise risk stratification into four groups: Low, Intermediate-1, Intermediate-2, and High.

How it works

Enter the patient's age (years) and check whether it is over 65.
Enter the hemoglobin level (g/dL) — values below 10 g/dL score 2 points.
Enter the white blood cell (WBC) count (×10⁹/L) — values above 25 score 1 point.
Enter the circulating blast percentage — 1% or more scores 1 point.
Indicate whether constitutional symptoms (fever, night sweats, weight loss >10% in 1 year) are present.
The calculator sums all points and assigns a risk group with median overall survival estimate.

Use cases

Stratify newly diagnosed myelofibrosis patients at any disease stage.
Guide discussion of transplant eligibility and timing based on risk category.
Support clinical decision-making for treatment intensification in intermediate or high-risk disease.
Communicate prognosis to patients and caregivers in clear, standardized terms.
Track prognostic category over time as disease parameters change.

Frequently Asked Questions

Last updated: 2026-06-15 · Reviewed by Nham Vu