What is the Reynolds Risk Score?

It is a sex-specific algorithm (Ridker et al., JAMA 2007) that predicts the probability a woman will have a heart attack, stroke, coronary revascularization, or cardiovascular death within 10 years. It adds hsCRP and parental MI history to the traditional Framingham variables, improving reclassification of about 40–50% of women previously labeled intermediate risk.

Why is hsCRP included?

High-sensitivity CRP is a marker of systemic inflammation. Inflammation plays a direct role in atherosclerosis. In the Women's Health Study, hsCRP was a stronger predictor of CV events than LDL cholesterol. Including it allows the Reynolds score to reclassify intermediate-risk women more accurately than cholesterol-only models.

What cholesterol units does this calculator use?

mg/dL, consistent with the original Reynolds publication. To convert mmol/L to mg/dL, multiply by 38.67 for total cholesterol and HDL. Typical total cholesterol in a healthy adult is 150–200 mg/dL; HDL above 60 mg/dL is considered protective.

What hsCRP value is normal?

An hsCRP below 1.0 mg/L is low cardiovascular risk. Between 1.0–3.0 mg/L is average risk. Above 3.0 mg/L indicates elevated inflammatory risk. Values above 10 mg/L may reflect acute infection or injury rather than chronic cardiovascular risk and should be retested after any acute illness resolves.

Is the Reynolds Risk Score validated for men?

A separate Reynolds Risk Score for men was published (Ridker et al., Circulation 2008), but this calculator implements the women's version. The male version uses hemoglobin A1c instead of family history as an additional variable. The two scores use different coefficients and should not be used interchangeably.

Is this a substitute for medical advice?

No. This is a clinical decision-support tool, not a replacement for a physician's evaluation. Risk estimates should be interpreted alongside your complete medical history, current medications, and other lab values. All treatment decisions must be made by a qualified clinician.

Reynolds Risk Score Calculator

Name: Reynolds Risk Score Calculator
Availability: InStock
Author: Nham Vu

Enter age, blood pressure, cholesterol, HDL, hsCRP, family history, and smoking to estimate your 10-year cardiovascular risk using the Reynolds Risk Score for women.

Patient Data (Women)

Age (years, 45–80)

Systolic Blood Pressure (mmHg)

Total Cholesterol (mg/dL)

HDL Cholesterol (mg/dL)

hsCRP (mg/L)

High-sensitivity C-reactive protein from a blood test. Values >10 mg/L may indicate acute illness — retest when healthy.

Current smoker Parent had heart attack before age 60

Enter patient data on the left and click Calculate Risk to see the 10-year cardiovascular risk estimate.

Summary