HOMA-IR Insulin Resistance Calculator

Enter your fasting glucose and fasting insulin values to instantly calculate your HOMA-IR insulin resistance index.

Use the HOMA-IR Insulin Resistance Calculator

Enter Fasting Lab Values

Normal fasting range: 70–99 mg/dL (3.9–5.5 mmol/L)

Also written as µIU/mL — numerically identical to mIU/L

Reference Ranges

Optimal < 1.0
Normal 1.0 – 1.9
Borderline Resistant 2.0 – 2.9
Insulin Resistant 3.0 – 4.9
Highly Resistant ≥ 5.0

Enter your fasting glucose and insulin values, then click Calculate.

Summary

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a widely used clinical index for estimating insulin resistance from a single fasting blood draw. It is calculated as (fasting glucose in mmol/L x fasting insulin in mIU/L) / 22.5. Values below 1.0 indicate excellent insulin sensitivity, while values above 2.0 suggest developing resistance and values above 3.0 indicate significant insulin resistance.

How it works

  1. Enter your fasting plasma glucose value and select the unit (mg/dL or mmol/L).
  2. Enter your fasting serum insulin value in mIU/L (also written as µIU/mL).
  3. The calculator converts glucose to mmol/L if needed, then applies the HOMA-IR formula.
  4. Your HOMA-IR score is displayed alongside an interpretation band (Optimal, Borderline, Resistant, Highly Resistant).
  5. Review the reference table to understand where your result falls relative to clinical thresholds.

Use cases

  • Screen for pre-diabetes or early metabolic syndrome.
  • Track insulin sensitivity improvements from diet or exercise changes.
  • Understand lab results before or after a doctor visit.
  • Compare fasting insulin values across different glucose units.
  • Research metabolic health and understand clinical HOMA-IR thresholds.
  • Support lifestyle interventions for weight management.

Frequently Asked Questions

Last updated: 2026-09-30 · Reviewed by Nham Vu