What time window does SLEDAI-2K cover?

SLEDAI-2K captures features present within the 10 days preceding the assessment. Unlike some other instruments, it counts a descriptor even if it is persistent and unchanged from a previous visit.

What score indicates a flare?

A commonly used definition of a mild-to-moderate flare is an increase in SLEDAI-2K of 3 or more points; a severe flare is defined as a new score of 12 or more, or a new score requiring hospitalisation or cytotoxic/high-dose steroid change. Individual trials may use different cut-offs.

What is the difference between SLEDAI and SLEDAI-2K?

The original SLEDAI (1992) counted rash, alopecia, mucosal ulcers, and pleuritis only if they were new or recurring; SLEDAI-2K (2002, Gladman et al.) scores these four descriptors whether new or persistent, making it more sensitive to ongoing activity. Most current publications use SLEDAI-2K.

Can this calculator replace clinical evaluation?

No. SLEDAI-2K is a structured clinical tool that supplements — not replaces — full rheumatological assessment, laboratory review, and shared decision-making. Always interpret the score in the complete clinical context.

What score indicates remission?

A SLEDAI-2K of 0 with or without maintenance therapy is commonly used as a definition of remission. Some treat-to-target guidelines accept a score of 4 or less (serological activity only) as clinical remission.

Does the calculator account for the SRI-50?

No. The SRI-50 (SLEDAI Responder Index) is a trial endpoint requiring a 50% reduction in SLEDAI score with no worsening in global assessment or new organ damage. This tool calculates the raw SLEDAI-2K score only.

SLEDAI Lupus Score Calculator

Name: SLEDAI Lupus Score Calculator
Availability: InStock
Author: Nham Vu

Select all present clinical and laboratory features of SLE in the past 10 days to compute the SLEDAI-2K total and disease activity classification.

Educational use only. This tool is intended for learning and reference purposes. SLEDAI-2K scores must be assessed and interpreted by a licensed clinician. Do not make treatment decisions based solely on this calculator.

Score Result

Select descriptors and click Calculate

Activity Classification

Score	Activity Level
0	No activity
1 – 5	Mild
6 – 10	Moderate
11 – 19	High
≥ 20	Very High

Summary

Select all present clinical and laboratory features of SLE in the past 10 days to compute the SLEDAI-2K total and disease activity classification.

How it works

Review the patient's clinical and laboratory findings from the past 10 days.
Check each descriptor that is currently present or active.
Each descriptor carries a fixed weight (1, 2, 4, or 8 points) reflecting clinical importance.
Click Calculate to sum all checked descriptors into the SLEDAI-2K total.
The result panel shows the total score, disease activity classification, and a domain breakdown.
Use the Reset button to clear all selections and start a new assessment.

Use cases

Track SLE disease activity serially at clinic visits to guide treatment decisions.
Determine flare versus remission for individual patients over time.
Stratify patients for clinical trial enrollment using a standardised activity threshold.
Communicate disease burden objectively between rheumatologists during referrals.
Monitor response to immunosuppressive therapy by comparing scores before and after.
Educate medical students and residents on the multisystem involvement of SLE.
Support treat-to-target strategies aiming for SLEDAI-2K of 0 or near-0.

Frequently Asked Questions

Last updated: 2026-07-01 · Reviewed by Nham Vu

SLEDAI Lupus Score Calculator

SLEDAI-2K Descriptors

Neuropsychiatric

Musculoskeletal

Renal

Skin

Serosal

Immunological

Constitutional