What is a normal A/G ratio?

A normal A/G ratio is generally 1.1 to 2.5. Values in this range indicate a healthy balance between albumin and globulin fractions. Reference ranges can vary slightly by laboratory.

What does a low A/G ratio mean?

A ratio below 1.1 often indicates either decreased albumin production (liver disease, malnutrition) or increased globulins (chronic inflammation, multiple myeloma, autoimmune disease, or HIV). A very low ratio warrants further workup.

What does a high A/G ratio mean?

A ratio above 2.5 can suggest low globulin levels, seen in some genetic immunodeficiency conditions or when globulin production is suppressed. Mildly elevated ratios are less clinically significant than low ratios.

Which units should I use?

You can enter values in either g/dL or g/L — the ratio itself is unitless because both values are divided. Just be consistent: both total protein and albumin must be in the same unit.

Can this replace a doctor's interpretation?

No. This calculator is a reference tool for educational purposes. Clinical interpretation requires consideration of the full panel, patient history, and symptoms. Always consult a healthcare provider.

Albumin-Globulin Ratio Calculator

Enter serum total protein and albumin to calculate globulin and the A/G ratio with instant interpretation.

Enter Lab Values

Unit

Total Protein (g/dL)

Normal: 6.0–8.3 g/dL (60–83 g/L)

Albumin (g/dL)

Normal: 3.5–5.0 g/dL (35–50 g/L)

Results

Enter values and click Calculate

Summary

The albumin-to-globulin (A/G) ratio compares two major protein fractions in blood serum: albumin (made by the liver) and globulins (a mix of immune and transport proteins). A normal A/G ratio typically falls between 1.1 and 2.5, and values outside this range can signal liver disease, kidney problems, autoimmune conditions, or hematologic disorders. This tool calculates globulin as total protein minus albumin, then divides albumin by globulin to produce the ratio.

How it works

Enter the serum total protein value (g/dL or g/L).
Enter the serum albumin value in the same unit.
The calculator subtracts albumin from total protein to derive globulin.
It divides albumin by globulin to get the A/G ratio.
An interpretation is shown based on the standard reference range.

Use cases

Interpreting routine liver function panels.
Monitoring patients with chronic liver disease or cirrhosis.
Evaluating nephrotic syndrome where albumin is lost in urine.
Assessing autoimmune or inflammatory conditions that raise globulins.
Tracking multiple myeloma or other dysproteinemias.
Double-checking lab arithmetic when reviewing patient records.

Frequently Asked Questions

Last updated: 2026-06-18 · Reviewed by Nham Vu