Drug Clearance Calculator
Enter volume of distribution and elimination half-life to compute drug clearance, elimination rate constant, and predicted steady-state concentration.
PK Parameters
Optional — Steady-State Trough
Results
Enter Vd and t½ then click Calculate.
Clearance (CL)
—
L/h
CL = 0.693 × Vd / t½
Elimination Rate Constant (ke)
—
h-1
ke = 0.693 / t½
Volume of Distribution (Vd)
—
L
Half-Life (t½)
—
hours
Predicted Steady-State Trough (Css,trough)
—
mg/L
One-compartment IV bolus model
Formulas Used
- CL = ln(2) × Vd / t½
- ke = ln(2) / t½
- Css,trough = (D / Vd) × e(−keτ) / (1 − e(−keτ))
For educational and research use only. Not a substitute for clinical pharmacokinetic evaluation by a qualified healthcare professional.
Summary
Enter volume of distribution and elimination half-life to compute drug clearance, elimination rate constant, and predicted steady-state concentration.
How it works
- Enter the volume of distribution (Vd) in liters or L/kg and the patient weight if using L/kg.
- Enter the elimination half-life (t½) in hours.
- Optionally enter dose and dosing interval to compute steady-state trough concentration.
- The calculator applies CL = (0.693 × Vd) / t½ and ke = 0.693 / t½.
- Results are displayed instantly with unit-labeled outputs and reference ranges.
Use cases
- Estimate clearance for pharmacokinetic modeling and drug dosing.
- Verify textbook PK parameter sets for antibiotics, analgesics, or anesthetics.
- Teach pharmacokinetics concepts to pharmacy and medical students.
- Compare clearance across patient populations with different body weights.
- Predict steady-state trough levels for therapeutic drug monitoring.
- Cross-check population PK parameters against individual patient estimates.