What is the Calvert formula?

The Calvert formula is: Carboplatin dose (mg) = Target AUC × (GFR + 25). GFR is typically estimated from the creatinine clearance using Cockcroft-Gault. The target AUC is prescribed by the oncologist and commonly ranges from 4 to 7 mg·min/mL depending on the regimen.

What AUC should I use?

The target AUC depends on the treatment regimen and patient condition. Common values are AUC 5–6 for combination regimens (e.g., with paclitaxel) and AUC 4–5 for heavily pre-treated patients. Always use the AUC specified in the oncology protocol — this calculator does not prescribe AUC.

Does this use ideal body weight or actual body weight?

This calculator uses actual body weight in the Cockcroft-Gault equation by default, which is standard for most carboplatin dosing guidelines. Some institutions cap weight at ideal body weight in obese patients — check your local protocol.

Is there a dose cap for carboplatin?

Many guidelines cap the GFR at 125 mL/min (per the Calvert formula) to avoid excessive dosing in patients with high GFR. This calculator applies that cap automatically. Some protocols also impose an absolute maximum dose — always verify against your institutional protocol.

How accurate is this calculator?

This tool is for educational and verification use only. Cockcroft-Gault provides an estimated GFR that may differ from measured GFR. Always confirm carboplatin doses with a pharmacist and the prescribing oncologist before administration.

Carboplatin AUC Dose Calculator

Name: Carboplatin AUC Dose Calculator
Availability: InStock
Author: Nham Vu

Calculate carboplatin chemotherapy dose (mg) using the Calvert formula with Cockcroft-Gault GFR estimation.

Patient & Dose Parameters

Age (years)

Sex

Male Female

Weight (kg)

Serum Creatinine (mg/dL)

Target AUC (mg·min/mL)

Common values: 4–5 (salvage), 5–6 (combination), 6–7 (single-agent)

Enter patient data and target AUC,
then click Calculate Dose.

Formula Reference

Dose (mg) = AUC × (GFR + 25)

GFR = CrCl via Cockcroft-Gault
CrCl = [(140 − age) × weight] / (72 × SCr)
× 0.85 if female
GFR capped at 125 mL/min

Source: Calvert AH et al., J Clin Oncol 1989. For verification only — confirm all doses with a pharmacist and oncologist.

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